PHARMOMICS: A SPECIES- AND TISSUE-SPECIFIC DRUG SIGNATURE DATABASE AND GENE-NETWORK-BASED DRUG REPOSITIONING TOOL

PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool

Summary: Drug development has been hampered by a high failure rate in clinical trials due to our incomplete understanding of drug functions across organs and species.Therefore, elucidating species- and tissue-specific drug functions can provide insights into therapeutic efficacy, potential adverse effects, and interspecies differences necessary for

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The Gap Between Global Tuberculosis Incidence and the First Milestone of the WHO End Tuberculosis Strategy: An Analysis Based on the Global Burden of Disease 2017 Database

Starter Packs Zhenyu Pan,1– 3 Jun Zhang,1,2,4 Qingting Bu,5 Hairong He,1 Ling Bai,1 Jin Yang,1,2 Qingqing Liu,1,2 Jun Lyu1,2,6 1Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2School of Public Health, Xi’an Jiaotong University Health Sci

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The foundations of the Patagonian icefields

Abstract The two vast Patagonian icefields are a global hotspot for ice-loss.However, not much is known about the total ice volume they store - let alone its spatial distribution.One reason is that the abundant record of direct thickness measurements has never been systematically exploited.Here, this record is combined with remotely-sensed informat

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